Directory of Peptide API Manufacturing Plants

Wuhan Vanz Pharm Inc.), located in Wuhan, Hubei Province, was established in 2011 (some B2B files are recorded as 2016). It is a API (API), pharmaceutical intermediates, fine chemicals, peptides and food additives that integrate R&D, production and sales. Its products are sold worldwide. The company has a R&D center of about 1000 square meters in Wuhan (including multiple synthesis laboratories, pilot amplification laboratories and analytical laboratories). The manufacturing base is equipped with 100L-5000L reactors, which can provide one-stop services from R&D to commercial production. With long-term cooperation from Shanghai Institute of Organic Chemistry and Wuhan University, it has completed more than 20 APIs and intermediates R&D. Business covers custom synthesis (CDMO/CMC orientation), API contract production, quality control and regulatory consulting. Note: The company uses small molecule APIs/intermediates and custom synthesis as its core business, and peptides is only one of its product categories, not a dedicated peptide API factory.

Wuhan Newtop Biotech Co., Ltd., located in Wuhan, Hubei, is a pharmaceutical manufacturing enterprise integrating R&D, production, sales and service, focusing on organic chemistry and pharmaceutical chemistry, with its own R&D center and laboratory. The company mainly focuses on polypeptides and pharmaceutical raw materials, including Semaglutide, Tirzepatide, Retatrutide, Cagrilintide, GHK-Cu, Melanotan, Thymosin alpha-1, LL-37, Selank, Epitalon, etc., and provides peptide freeze-dried powder and raw materials. With peptide synthesis, purification and active ingredient separation capabilities, the production system has obtained GMP, ISO 9001, HSE and other quality certifications, and has a D-level (ISO 8)/C-level (ISO 7) clean workshop; products are mainly exported to Europe, the United Kingdom, the United States, Canada, Australia and other countries and regions.

Chongqing Zhixia Chemical Co., Ltd. (related to Nanjing Chenruisheng Biomedical Technology) was established in September 2023. It is a small and micro enterprise, mainly engaged in the research and development and supply of polypeptide GLP-1 raw materials, representing products including Semaglutide, Tirzepatide and other polypeptide raw materials. The business model is factory, customization and service, and the products are mostly marked as "for scientific research or export only". The company announced a registered capital of 500,000 yuan, 10–50 employees, and an annual turnover of about 3-5 million yuan. The contact information is shared with Nanjing Chen Ruisheng (the same phone/email address), and is positioned as a peptide small molecule GLP-1 raw material supplier for the global scientific research and export market.

Sichuan Ampelbo Biotechnology Co., Ltd. (Chengdu Boke Pharmaceutical Technology Co., Ltd., Chengdu) is a professional R&D, production and sales of amino acid derivatives (amino alcohols, amino aldehydes, N-methyl amino acids, amino acid tert-butyl esters, Boc/Fmoc/Cbz protected amino acids, benzyl esters, amino acid amides, etc.). It also provides polypeptides, piperidine derivatives and chiral amine series products. It can provide domestic and foreign customers with high-quality pharmaceutical intermediates and fine chemicals from grams, kilograms to tons. Its products are exported to Europe and North America. It is a small high-tech/trade-oriented enterprise (with a staff size of about 8–50 people). The polypeptide is one of its product lines, with a partial amino acid protecting group and a polypeptide side chain/intermediate direction.

Shanghai QYAOBIO Co., Ltd. (ChinaPeptides/QYAOBIO), founded in October 2008, is a technology-based enterprise focusing on peptide synthesis, protein expression, and antibody preparation. In China, peptide solid phase synthesis (SPPs) technology was adopted earlier. The company maturely mastered 300 + peptide special modification core technologies, and has branches and scientific research laboratories in Suzhou, Wuhan, and Ezhou; cumulatively serving more than 50,000 customers worldwide, covering more than 50 countries and China's Hong Kong, Macao, and Taiwan regions, of which more than 90% are biomedical research institutions and pharmaceutical companies such as universities, hospitals, laboratories, and research institutes. Has passed ISO 9001: 2015 quality system certification, > 99% peptide synthesis success rate, provide HPLC/MS report and optional endotoxin/salt type test, as soon as 3 days delivery; core business is peptide synthesis, protein expression and antibody preparation.

Focus on overseas Biohacking channels, mature composite peptide kits

Nanjing Yuanpeptide Biotechnology Co., Ltd. (Yuanpeptide Biotechnology) was established in 2018 and is located in the Biomedical Valley/Zhongdan Ecological Life Science Industrial Park in Jiangbei New District of Nanjing. It is a science and technology-based small and medium-sized enterprise (selected as a science and technology-based small and medium-sized enterprise in Jiangsu Province in 2025) that focuses on the synthesis of scientific research peptides and customized services. The company has 46 employees, an independent research and development center and 900 square meters of sterile laboratory, 4 standardized peptide production lines, equipped with Waters LC-MS/MS, UPLC, automatic purification system, automatic lyophilization system and other precision instruments, with a peak monthly production capacity of about 3000 peptides. Stable synthesis of conventional linear peptides and 60 amino acid long peptides, 100 amino acid super long peptides, specializing in polydithiocyclic peptides, head and tail closed-loop peptides, book peptides, highly hydrophobic membrane penetrating peptides, D-type amino acid peptides, glycopeptides, lipopeptides and other complex structures; modified types cover phosphorylation, sulfonation, methylation, acetylation, pegylation, biotin labels, a variety of fluorescent labels (FITC/Cy series), isotope labels (13c/15N), protein cross-linking and more than 300 kinds. Service ranges from milligrams to kilograms, and long-term cooperation with universities and medical institutions such as Nanjing University, Fudan, Shanghai Jiaotong University, and West China Hospital.

Hefei Peptide Library Biotechnology Co., Ltd. (Taikubio) is a high-tech enterprise committed to peptide synthesis research and peptide custom synthesis. The core team has a background in the chemical industry at home and abroad and rich R&D and management experience. The company has 1500 square meters of office/experimental space, equipped with precision instruments such as Waters LC-MS/MS, UPLC, automatic purifier, Shimadzu LCMS, and automatic lyophilization system; thousands of catalog peptides such as polypeptides/pet probe precursors are available in stock, and more than 400 kinds of modification and drug coupling technology routes are accumulated, which can undertake milligram to kilogram level production, covering the comprehensive needs of scientific research and customization and from small-scale trials, pilot trials to large-scale production. Mainly engaged in peptide API intermediates, cosmetic peptides, customized peptides, and HPLC purification and bioassay services; can be customized to produce pet probe precursors (FAPI, PSMA, polypeptides, NEB, etc.) and related intermediates. It has established cooperation with universities such as Peking University, Tsinghua University, Zhejiang University and foreign pharmaceutical companies.

Founded in 2013 in Hefei, Cellmano Biotech Limited is a high-tech company focused on the research and industrialization of solid phase peptide synthesis methods. The company has been engaged in the R&D and manufacturing of solid-phase polypeptide synthesis since 2011. It has a R&D center that meets the requirements of solid-phase synthesis, lyophilization and purification, and a complete set of analytical and testing instruments. The synthesis records, purification methods and test reports of each batch of products are archived in detail. Its main business includes peptide intermediates, cosmetic peptides (cosmetic peptides), custom synthesis of peptides, and peptide CMO services. It can provide customized peptides from mg to kg, from crude to 98% purity, and establish more than 2,000 commonly used catalog peptides in stock (gradually improve inventory, deliver in as fast as one week) to serve customers around the world. Approximately 10–50 employees.