Mazdutide Dosing Protocol: 10 mg Vial — Full Titration & Maintenance Guide
Quickstart highlights
Mazdutide (IBI362) simultaneously activates GLP-1 receptors (insulin secretion, glucagon suppression, appetite reduction) and glucagon receptors (hepatic fat oxidation, thermogenesis, glycogenolysis).
- Concentration: 5 mg/mL (10 mg vial + 2 mL bacteriostatic water).
- At 5 mg/mL: 3 mg = 60 units (0.6 mL), 6 mg = 120 units (1.2 mL), 9 mg = 180 units (1.8 mL).
- GLORY-1 Phase 3: 6 mg once weekly achieved 14.5% body weight reduction at 36 weeks.
- Use a 3 mL syringe for the 6 mg and 9 mg doses — volumes exceed 1 mL.
- One 10 mg vial provides ~1.67 doses at 6 mg/week; plan weekly reconstitution at this dose level.
Dosing table
For educational reference only. Your prescribing provider may adjust doses based on your clinical profile and response.
| Week | Dose (µg) | Units | Frequency | Notes |
|---|---|---|---|---|
| 1-8 | 3000 | 60 | Once weekly | 3 mg — 60 units; 10 mg vial provides ~3.3 doses at this level |
| 9-16 | 6000 | 120 | Once weekly | 6 mg maintenance — 120 units (1.2 mL); use 3 mL syringe; vial provides ~1.67 doses |
| 17+ | 9000 | 180 | Once weekly | 9 mg high-dose — 180 units (1.8 mL); GLORY Phase 3 high-dose arm; approximately 1.11 doses per vial |
Your free Mazdutide tracker
- Dose reminders
- Injection logging
- Cycle progress
Reconstitution steps
- Draw 2 mL bacteriostatic water; inject slowly down the vial wall.
- Swirl gently until fully dissolved; do not shake.
- Final concentration: 5 mg/mL (10 mg / 2 mL). For 6 mg dose: draw 1.2 mL; for 9 mg: draw 1.8 mL — use 3 mL syringe.
- Label with date; refrigerate at 2–8 °C. Use within 28 days.
Supplies needed
8-week plan
- 1 vial
- 8 syringes
- 2 mL bac water
- 8 alcohol swabs
16-week plan
- 4 vials
- 16 syringes
- 8 mL bac water
- 16 alcohol swabs
24-week plan
- 6 vials
- 24 syringes
- 12 mL bac water
- 24 alcohol swabs
Protocol overview & cycle notes
Provide full-cycle mazdutide coverage from 3 mg initiation through 6–9 mg maintenance using the 10 mg vial, supporting weight loss and glycemic control via dual GLP-1/glucagon agonism per the GLORY Phase 3 protocol.
Cycle length: 24 weeks on.
Off-cycle: 8–12 weeks off; monitor HbA1c and body weight.
Storage & handling
Injection & tracking tips
- Use a 3 mL syringe for doses above 5 mg — the 6 mg dose requires 1.2 mL, exceeding a standard 1 mL U-100 syringe.
- Rotate injection sites weekly.
- Hydration is important at higher doses — maintain ≥2 L water daily, especially at 9 mg where glucagon effects increase urinary output.
Tracking
Logging helps you and your provider spot patterns and adjust dose or timing.
- Record body weight weekly; GLORY-1 Phase 3 showed 14.5% weight reduction at 6 mg over 36 weeks.
- Track fasting blood glucose and HbA1c every 8 weeks.
- Monitor ALT/AST monthly at doses ≥6 mg; the glucagon component increases hepatic enzyme activity transiently.
How this works & references
Frequently asked questions
How many 10 mg vials do I need for a 16-week titration?
Can mazdutide treat fatty liver disease?
Is 9 mg the maximum dose?
How does mazdutide perform compared to semaglutide for T2DM?
What is the off-cycle protocol?
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View protocolThis content is for informational purposes only and does not constitute medical advice. Consult a licensed healthcare provider before starting any peptide therapy. Dosing and protocols may vary by formulation and prescriber.