DSIP
Neuropeptide
Overview
Delta-sleep-inducing peptide (DSIP) is a neuropeptide that when infused into the mesodiencephalic ventricle of recipient rabbits induces spindle and delta EEG activity and reduced motor activities.
Its amino acid sequence is Trp-Ala-Gly-Gly-Asp-Ala-Ser-Gly-Glu (WAGGDASGE). The gene has yet to be found in rabbits, along with any receptors or precursor peptides. However, searches through BLAST have found that it aligns with a hypothetical Amycolatopsis coloradensis protein. This could indicate that DSIP has a bacterial origin.
Source: English Wikipedia, "Delta-sleep-inducing peptide".
Mechanism of Action
Many roles for DSIP have been suggested following research carried out using peptide analogues with a greater molecular stability and through measuring DSIP-like immunological (DSIP-LI) response by injecting DSIP antiserum and antibodies.
Roles in endocrine regulation Decreases basal corticotropin level and blocks its release.
Stimulates release of luteinizing hormone (LH). Stimulates release of somatoliberin and somatotrophin secretion and inhibits somatostatin secretion.
Roles in physiological processes Can act as a stress limiting factor.
May have a direct or indirect effect on body temperature and alleviating hypothermia.