Tesamorelin Dosing Protocol: 10 mg Vial — Extended Supply Dosing Guide
Quickstart highlights
Tesamorelin's FDA-approved 2 mg/day protocol demonstrated 15.2% visceral fat reduction at 26 weeks in Phase 3 (Falutz et al., 2010).
- Concentration: 2 mg/mL (10 mg vial + 5 mL bacteriostatic water).
- At 2 mg/mL: 2 mg = 100 units (full 1 mL) once daily — the FDA-approved Egrifta SV dose.
- One 10 mg vial provides exactly 5 daily doses at 2 mg — reconstitute twice weekly.
- Phase 3 (Falutz et al.): 2 mg/day x 26 weeks reduced visceral fat 15.2% vs. 0.7% placebo.
- Refrigerate; use within 28 days.
Dosing table
For educational reference only. Your prescribing provider may adjust doses based on your clinical profile and response.
| Week | Dose (µg) | Units | Frequency | Notes |
|---|---|---|---|---|
| 1-4 | 1000 | 50 | Once daily | 1 mg — 50 units; 10 mg vial provides 10 doses at this level (10 days) |
| 5-26 | 2000 | 100 | Once daily | 2 mg — 100 units (FDA-approved dose); 10 mg vial provides 5 daily doses (5 days) |
Your free Tesamorelin tracker
- Dose reminders
- Injection logging
- Cycle progress
Reconstitution steps
- Draw 5 mL bacteriostatic water in two 2.5 mL draws; inject slowly down the vial wall.
- Swirl gently until powder dissolves fully; do not shake.
- Final concentration: 2 mg/mL. Label with date; refrigerate at 2–8 °C. Use within 28 days.
- One 10 mg vial covers 5 daily doses at 2 mg — plan reconstitution twice weekly at the 2 mg/day maintenance dose.
Supplies needed
12-week plan
- 12 vials
- 84 syringes
- 60 mL bac water
- 84 alcohol swabs
26-week plan
- 37 vials
- 182 syringes
- 185 mL bac water
- 182 alcohol swabs
Protocol overview & cycle notes
Reduce visceral adipose tissue through twice-weekly reconstitution of tesamorelin 10 mg vials at the 2 mg/day FDA-approved dose, providing 5 days of injections per reconstitution event.
Cycle length: 26 weeks on.
Off-cycle: 8 weeks off; measure IGF-1 and visceral fat surrogate (waist circumference) before resuming.
Storage & handling
Injection & tracking tips
- Reconstitute twice weekly at the 2 mg/day dose — one 10 mg vial covers exactly 5 daily injections.
- Inject at the same time daily (morning preferred) in the abdomen, 2 inches from the navel; rotate within quadrants.
- Store used vials cap-side down in the refrigerator door; inspect for cloudiness before each draw.
Tracking
Logging helps you and your provider spot patterns and adjust dose or timing.
- Measure waist circumference weekly as a visceral fat proxy.
- Track IGF-1 every 8 weeks; target upper-normal for age.
- Monitor fasting glucose monthly; tesamorelin can increase glucose by 5–10 mg/dL in insulin-resistant patients.
How this works & references
Sources
- Metabolic effects of a growth hormone-releasing factor in patients with HIV. Falutz J et al. — N Engl J Med — 2007
- FDA — Egrifta SV (tesamorelin) Prescribing Information, 2019
- Population pharmacokinetic analysis of tesamorelin in HIV-infected patients and healthy subjects. González-Sales M et al. — Clin Pharmacokinet — 2015
- Effects of tesamorelin, a growth hormone-releasing factor, in HIV-infected patients with abdominal fat accumulation: a randomized placebo-controlled trial with a safety extension. Falutz J et al. — J Acquir Immune Defic Syndr — 2010
Frequently asked questions
How many 10 mg vials do I need for a 26-week protocol at 2 mg/day?
Is the 10 mg vial significantly more convenient than the 5 mg vial?
Can tesamorelin be used for weight loss in non-HIV patients?
Does tesamorelin improve triglycerides as well as visceral fat?
What are the signs of excessive tesamorelin dose?
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