Semaglutide 10 mg Vial Dosing Protocol
Quickstart highlights
Semaglutide is a GLP-1 receptor agonist that enhances insulin secretion and suppresses appetite.
- Concentration: 6.67 mg/mL (10 mg vial + 1.5 mL bac water).
- Dose range: 300 µg (Week 1–2) up to 1,000 µg (maintenance) once weekly.
- At 6.67 mg/mL, 1 unit ≈ 66.7 µg; draw 4.5 units for 300 µg, 15 units for 1,000 µg.
- A single 10 mg vial yields roughly 10 doses at 1,000 µg maintenance — more cost-effective than a 5 mg vial for longer cycles.
Dosing table
For educational reference only. Your prescribing provider may adjust doses based on your clinical profile and response.
| Week | Dose (µg) | Units | Frequency | Notes |
|---|---|---|---|---|
| 1-2 | 300 | 4.5 | Once weekly | Starting dose — draw to 4.5 units on a U-100 syringe |
| 3-4 | 600 | 9 | Once weekly | Pause if GI side effects persist |
| 5-6 | 1000 | 15 | Once weekly | Maintenance — at 6.67 mg/mL, 15 units = 1,000 µg |
Gradual approach
| Week | Dose (µg) | Units | Notes |
|---|---|---|---|
| 1-4 | 250 | 3.75 | Slower ramp — use a 30-unit syringe, draw to 3.75 units |
| 5-8 | 500 | 7.5 | Increase only if tolerating well |
| 9+ | 1000 | 15 | Maintenance — 15 units on a U-100 syringe |
Your free Semaglutide 10 mg Vial tracker
- Dose reminders
- Injection logging
- Cycle progress
Reconstitution steps
- Use 1.5 mL bacteriostatic water; inject slowly down the vial wall to yield 6.67 mg/mL.
- Gently swirl until fully dissolved; do not shake.
- Label the vial with reconstitution date; refrigerate 2–8 °C.
Supplies needed
8-week plan
- 1 vial
- 8 syringes
- 2 mL bac water
- 8 alcohol swabs
16-week plan
- 1 vial
- 16 syringes
- 2 mL bac water
- 16 alcohol swabs
24-week plan
- 2 vials
- 24 syringes
- 4 mL bac water
- 24 alcohol swabs
Protocol overview & cycle notes
Support weight management with a GLP-1 agonist titration using a 10 mg compounded vial. Higher concentration means fewer units per dose; a single vial covers 6–10+ weeks at maintenance.
Cycle length: 12 weeks on.
Off-cycle: 8 weeks off between cycles; monitor mood and energy during off-cycle.
Storage & handling
Injection & tracking tips
- Rotate injection sites (abdomen, thigh, upper arm) to reduce irritation.
- At 6.67 mg/mL the unit counts are roughly half those of a 5 mg vial — double-check your math before drawing each dose.
Tracking
Logging helps you and your provider spot patterns and adjust dose or timing.
- Log injection date, dose (units), and injection site.
- Track appetite, energy, and any side effects weekly.
How this works & references
Sources
- Once-Weekly Semaglutide in Adults with Overweight or Obesity. Wilding JPH et al. — N Engl J Med — 2021
- FDA – Wegovy (semaglutide) prescribing information
- Clinical Pharmacokinetics of Semaglutide: A Systematic Review. Yang XD et al. — Drug Des Devel Ther — 2024
- Pharmacokinetics, Safety and Tolerability of Once-Weekly Subcutaneous Semaglutide in Healthy Chinese Subjects: A Double-Blind, Phase 1, Randomized Controlled Trial. Shi A et al. — Adv Ther — 2021
Frequently asked questions
How much bac water do I add to a 10 mg semaglutide vial?
How many doses are in a 10 mg vial?
Is a 10 mg vial better than a 5 mg vial?
What syringes do I use for a 10 mg vial?
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View protocolThis content is for informational purposes only and does not constitute medical advice. Consult a licensed healthcare provider before starting any peptide therapy. Dosing and protocols may vary by formulation and prescriber.